Teacher
Catarina Maria Roma Rodrigues

Resume

Catarina Roma-Rodrigues is a assistant professor at Engineering faculty of Universidade Lusófona de Lisboa. She completed her PhD in Biotechnology at the Universidade de Lisboa Instituto Superior Técnico, Msc in Biotechnology (Biochemical Engineering) at the same university, and her Bsc in Biochemistry at the Universidade de Lisboa Faculdade de Ciências. Her work as Postdoc at Unidade de Ciências Biomoleculares aplicadas in Nova School of Sciences and Technology was mainly focused on the role of exosomes in the modulation of the tumor microenvironment, and in the biologic effect of compounds with chemotherapeutic potential on tumor cells. She published 68 articles in peer-reviewed international journals, being cited 2,467 times (without self-citations), and having a h-index of 23, being considered as the top 2% tier of world's scientists since 2022 (DOI:10.17632/btchxktzyw.5) . Organized two events and participated in the scientific committee of 2 events. Supervised 5 MSc dissertations and 2 works of course completion of BSc. She participated as a PhD Student Fellow in 1 project, a Post-doc Fellow in 3 projects, a Principal Investigator in 1 project, a Research Fellow in 3 projects, and a Researcher in 3 projects. She has experience in higher education at several academic institutions, including Nova school of sciences and technologies, Lusofona university and Egas Moniz school of health and science.

Graus

• Licenciatura
  Bioquímica
• Mestrado
  Biotecnologia (Engenharia Bioquímica)
• Doutoramento
  Biotecnologia

Publicações

Journal article

• 2024-10-16, Discovery of Novel Fluorescent Azaindoles with Cytotoxic Action in A2780 Ovarian Carcinoma Cells, ChemMedChem
• 2024-09-13, Evaluation of Biotechnological Active Peptides Secreted by Saccharomyces cerevisiae with Potential Skin Benefits, Antibiotics , MDPI
• 2024, Exploring the synthesis of aminal guanidine-based molecules: synthesis of cernumidine and analogues, and survey of its anti-inflammatory activity, New Journal of Chemistry
• 2024, Exploring The Synthesis of Aminal Guanidine-Based Molecules: Synthesis of Cernumidine and Analogues, and Survey of its Antiinflammatory Activity , New Journal of Chemistry
• 2023-02-23, Exploring RAB11A Pathway to Hinder Chronic Myeloid Leukemia-Induced Angiogenesis In Vivo, Pharmaceutics
• 2023-02-10, Cell Uptake of Steroid-BODIPY Conjugates and Their Internalization Mechanisms: Cancer Theranostic Dyes, International Journal of Molecular Sciences
• 2023-02-04, Chitin-Glucan Complex Hydrogels: Physical-Chemical Characterization, Stability, In Vitro Drug Permeation, and Biological Assessment in Primary Cells, Polymers
• 2023, Tackling Imatinib Resistance via Au-nanoconjugates using A Cml Resistant Cell Line, Particle & Particle Systems Characterization
• 2023, Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol: Design, Characterization and Biological Properties
• 2023, Exploring the Multifaceted Potential of a Peptide Fraction Derived from Saccharomyces cerevisiae Metabolism: Antimicrobial, Antioxidant, Antidiabetic, and Anti-Inflammatory Properties
• 2022-11-30, Antiproliferative Activity of Buddleja saligna (Willd.) against Melanoma and In Vivo Modulation of Angiogenesis, Pharmaceuticals
• 2022-11-06, In Vitro and In Vivo Biological Activity of Ruthenium 1,10-Phenanthroline-5,6-dione Arene Complexes, International Journal of Molecular Sciences
• 2022, Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma, Journal of Materials Chemistry B
• 2021-11-19, Genetic Biomarkers in Chronic Myeloid Leukemia: What Have We Learned So Far?, International Journal of Molecular Sciences
• 2021-08-18, Evaluation of the In Vitro and In Vivo Efficacy of Ruthenium Polypyridyl Compounds against Breast Cancer, International Journal of Molecular Sciences
• 2021-06, Square planar Au(III), Pt(II) and Cu(II) complexes with quinoline-substituted 2,2':6',2¿-terpyridine ligands: From in vitro to in vivo biological properties, European Journal of Medicinal Chemistry
• 2021-03-03, In Vitro and In Vivo Effect of Palladacycles: Targeting A2780 Ovarian Carcinoma Cells and Modulation of Angiogenesis, Inorganic Chemistry
• 2021-03, Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease, Food and Chemical Toxicology
• 2021-02-11, Half-Sandwich Ru(p-cymene) Compounds with Diphosphanes: In Vitro and In Vivo Evaluation As Potential Anticancer Metallodrugs, Inorganic Chemistry
• 2021-02-09, Combined cancer therapeutics—Tackling the complexity of the tumor microenvironment, WIREs Nanomedicine and Nanobiotechnology
• 2021-01, Exploiting the antiproliferative potential of spiropyrazoline oxindoles in a human ovarian cancer cell line, Bioorganic & Medicinal Chemistry
• 2021, Triazole-Based Half-Sandwich Ruthenium(II) Compounds: From in Vitro Antiproliferative Potential to in Vivo Toxicity Evaluation, Inorganic Chemistry
• 2021, New Insights on Streptococcus dysgalactiae subsp. dysgalactiae Isolates, Frontiers in Microbiology
• 2020-10-28, Hyperthermia Induced by Gold Nanoparticles and Visible Light Photothermy Combined with Chemotherapy to Tackle Doxorubicin Sensitive and Resistant Colorectal Tumor 3D Spheroids, International Journal of Molecular Sciences
• 2020-09-01, The Intracellular Number of Magnetic Nanoparticles Modulates the Apoptotic Death Pathway after Magnetic Hyperthermia Treatment, ACS Applied Materials & Interfaces
• 2020-04-14, Synthesis of New Hetero-Arylidene-9(10H)-Anthrone Derivatives and Their Biological Evaluation, Bioorganic Chemistry
• 2020-03-05, Gene Therapy in Cancer Treatment: Why Go Nano?, Pharmaceutics
• 2020-02-01, Size-Dependent Biological Activities of Fluorescent Organosilane-Modified Zinc Oxide Nanoparticles, Journal of Biomedical Nanotechnology
• 2020-01, Zn(II) and Co(II) derivatives anchored with scorpionate precursor: Antiproliferative evaluation in human cancer cell lines, Journal of Inorganic Biochemistry
• 2019-12-01, Liquid biopsies in myeloid malignancies, Cancer Drug Resistance
• 2019-11-23, Cation-mediated gelation of the fucose-rich polysaccharide FucoPol: preparation and characterization of hydrogel beads and their cytotoxicity assessment, International Journal of Polymeric Materials and Polymeric Biomaterials
• 2019-08-14, Nanotheranostics Targeting the Tumor Microenvironment, Frontiers in Bioengineering and Biotechnology
• 2019-08, Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles, International Journal of Nanomedicine
• 2019-07, Structural characterization and biological properties of silver(I) tris(pyrazolyl)methane sulfonate., Journal of inorganic biochemistry
• 2019-06, Occurrence of non-toxic bioemulsifiers during polyhydroxyalkanoate production by Pseudomonas strains valorizing crude glycerol by-product, Bioresource Technology
• 2019-05, Biofilm development and computational screening for new putative inhibitors of a homolog of the regulatory protein BrpA in Streptococcus dysgalactiae subsp. dysgalactiae, International Journal of Medical Microbiology
• 2019-04-03, Structural aspects of a trimetallic CuII derivative: cytotoxicity and anti-proliferative activity on human cancer cell lines, Journal of Coordination Chemistry
• 2019-02-15, Targeting Tumor Microenvironment for Cancer Therapy, International Journal of Molecular Sciences
• 2019-01-28, GLUT1 and GLUT3 involvement in anthocyanin gastric transport- Nanobased targeted approach, Scientific Reports
• 2018-09-03, Front Cover: The Important Role of the Nuclearity, Rigidity, and Solubility of Phosphane Ligands in the Biological Activity of Gold(I) Complexes (Chem. Eur. J. 55/2018), Chemistry - A European Journal
• 2018-09, A new Cu(II)-O-Carvacrotinate complex: Synthesis, characterization and biological activity., Journal of inorganic biochemistry
• 2018-05-01, Spectroscopy, electrochemistry and antiproliferative properties of Au(iii), Pt(ii) and Cu(ii) complexes bearing modified 2,2':6',2''-terpyridine ligands, Dalton Transactions
• 2018-04-24, EPR and electrochemical interpretation of bispyrazolylacetate anchored Ni(ii) and Mn(ii) complexes: cytotoxicity and anti-proliferative activity towards human cancer cell lines, New Journal Chemistry
• 2018-03-25, Streptococcus dysgalactiae subsp. dysgalactiae isolated from milk of the bovine udder as emerging pathogens: In vitro and in vivo infection of human cells and zebrafish as biological models, MicrobiologyOpen
• 2018-01-26, Synthesis, Cytotoxicity Evaluation in Human Cell Lines and in Vitro DNA Interaction of a Hetero-Arylidene-9(10H )-Anthrone, European Journal of Organic Chemistry
• 2018-01-23, Convergence of miR-143 overexpression, oxidative stress and cell death in HCT116 human colon cancer cells, PLOS ONE
• 2018, The Important Role of the Nuclearity, Rigidity, and Solubility of Phosphane Ligands in the Biological Activity of Gold(I) Complexes, Chemistry - A European Journal
• 2018, Synthesis of tetrahydro-1H-indolo[2,3-b]pyrrolo[3,2-c]quinolones via intramolecular oxidative ring rearrangement of tetrahydro-ß-carbolines and their biological evaluation, New Journal of Chemistry
• 2018, Important cytotoxic and cytostatic effects of new copper(i)–phosphane compounds with N,N, N,O and N,S bidentate ligands, Dalton Transactions
• 2017-11, Understanding the response of Desulfovibrio desulfuricans ATCC 27774 to the electron acceptors nitrate and sulfate - biosynthetic costs modulate substrate selection, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
• 2017-10, Mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes as potential antiproliferative agents, Journal of Inorganic Biochemistry
• 2017-06-06, Dinuclear RuII(bipy)2Derivatives: Structural, Biological, and in Vivo Zebrafish Toxicity Evaluation, Inorganic Chemistry
• 2017-05, Smuggling gold nanoparticles across cell types – A new role for exosomes in gene silencing, Nanomedicine: Nanotechnology, Biology and Medicine
• 2017-02-02, Targeting canine mammary tumours via gold nanoparticles functionalized with promising Co(II) and Zn(II) compounds, Veterinary and Comparative Oncology
• 2017-01-14, Tumor Microenvironment Modulation via Gold Nanoparticles Targeting Malicious Exosomes: Implications for Cancer Diagnostics and Therapy, International Journal of Molecular Sciences
• 2017, Copper(ii) complexes of functionalized 2,2':6',2''-terpyridines and 2,6-di(thiazol-2-yl)pyridine: structure, spectroscopy, cytotoxicity and catalytic activity, Dalton Transactions
• 2016-12-21, Heteroleptic mononuclear compounds of ruthenium(ii): synthesis, structural analyses, in vitro antitumor activity and in vivo toxicity on zebrafish embryos., Dalton Transactions
• 2016-12-15, A quantitative proteomic approach to highlight Phragmites sp. adaptation mechanisms to chemical stress induced by a textile dyeing pollutant, Science of The Total Environment
• 2016-06-07, Peptide-coated gold nanoparticles for modulation of angiogenesis in vivo, International Journal of Nanomedicine
• 2016-05-03, Immortalization and characterization of a new canine mammary tumour cell line FR37-CMT, Veterinary and Comparative Oncology
• 2016-04, Infection of human keratinocytes by Streptococcus dysgalactiae subspecies dysgalactiae isolated from milk of the bovine udder, Microbes and Infection
• 2015-10, MicroRNAs Based Therapy of Hypertrophic Cardiomyopathy: The Road Traveled So Far, BioMed Research International
• 2015-09-16, Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box, Molecules
• 2015-06-16, Characterization of antiproliferative potential and biological targets of a copper compound containing 4'-phenyl terpyridine, JBIC Journal of Biological Inorganic Chemistry
• 2014-10, Genetics of hypertrophic cardiomyopathy: advances and pitfalls in molecular diagnosis and therapy, The Application of Clinical Genetics
• 2014-05, Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells, BioMed Research International
• 2010-06, Response of Pseudomonas putida KT2440 to phenol at the level of membrane proteome, Journal of Proteomics
• 2009-09, Teaching expression proteomics: From the wet-lab to the laptop, Biochemistry and Molecular Biology Education

Book chapter

• 2023, Gold Nanoparticles as a Tool for Combinatorial Nanomedicine, 1, World Scientific Publishing Company

Conference paper

• 2011, OMICS approaches to reveal Burkholderia cenocepacia adaptive strategies to long-term residence in the lungs of cystic fibrosis patients under antibiotic therapy, 1st Portuguese meeting in bioengineering

Conference abstract

• 2022-12-12, Short Lecture 4 “Evaluation of antiproliferative and anti-angiogenic activity of an ethanolic extract of Helichrysum odoratissimum (L.) Sweet against skin cancer”
• 2010-10-08, The response of Phragmites’ sp. during Acid Orange 7 phytoremediation through proteomic analysis, 12th International Conference on Wetland Systems for Water Pollution Control

Conference poster

• 2023-06-22, Gold nanoparticles for iRNA: inhibition of inter-cellular communication mediated by cancer cells derived exosomes, 2nd PNEV meeting
• 2020-03-03, abstract P-360: Modulating exosome biogenesis using gold nanoparticles to inhibit Chronic Myeloid Leukemia microenvironment progression, EACR-AACR-ASPIC ‘Basic and Translational Research Conference Tumor Microenvironment’
• 2019-08-04, Repurposing Old Drugs to do New Tricks – The use of- Thioridazine to treat multi-drug resistant infections, Microbiology society annual meeting
• 2019-07-24, Synthesis of New Hetero-Arylidene-9(10H)-Anthrone Derivatives and Biological Evaluation as Antiproliferative Agents, XXVI Encontro Nacional da Sociedade Portuguesa de Química
• 2016-05-30, In vitro and in vivo examination of S. dysgalactiae subsp. dysgalactiae virulence and host-pathogen interactions using human cells and zebrafish (Danio renio) as biological models, 2º Workshop Genética
• 2015-02-02, miR-143 and miR-145 overexpression in HCT116 colon cancer cells enhances cetuximab-mediated antibody-dependent cellular cytotoxicity leading to increased apoptosis, Cancer Epigenetics and Metabolism: Connecting the dots meeting
• 2015, Evolution of bovine mastitis Streptococcus dysgalactiae subps. dysgalactiae isolates from Portugal, Microbiotec'15
• 2015, Analysis of adherence and internalization into human cells by bovine mastitis Streptococcus dysgalactiae subsp. dysgalactiae, Microbiotec’15
• 2014-11-09, Insights into infection potential of Streptococcus pyogenes strains with different clinical origins, XIX Lancefield
• 2012-09-05, ß-Myrcene biotransformation by Pseudomonas sp. M1, 43rd International Simposium of Essential Oils
• 2010-07-23, Proteomics applied to phytoremediation, 4th EuPA Meeting and 6th ProCuraMeeting
• 2009-04-15, Expression Proteomics at the BSRG, 1º encontro do IBB - Instituto de Biotecnologia e Bioengenharia
• 2007, Membrane proteomics of Pseudomonas putida KT2440 under phenol stress, MicroBiotec’07
• 2005-09-18, Temperature effects in Chlamydomonas reinhardtii rubisco mutants, IX congresso Luso Espanhol de Fisiologia Vegetal
• 2004-12-02, Mutagenesis of tyrosine residues from rubisco cause decrease in carboxylic activity of the enzyme, XIV congresso de Bioquímica
• 2003-06-29, Peptides, aminoacids and biogenic amines in Lactobacillus – interactions and metabolism, 1st encounter of the Federation of European Microbiological Societies

Other output

• 2020-10, 3D cell culture model for drug screening purposes, Case study for Cytosmart - Lux3 FL