Docente
Bruno Costa Gomes

Resume

Bruno Daniel Costa Gomes has an extensive educational background, starting with a Bachelor’s degree in Biology from Universidade Lusófona de Humanidades e Tecnologias, Portugal (2002-2008). He then pursued a Doctorate in Life Sciences with specialization in Genetics, Human Toxicology and Oncology from Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal (2010-2016), where he graduated Summa Cum Laude. His thesis was titled “microRNA involvement in breast cancer susceptibility and progression”. Bruno has completed several postgraduate courses and other training, including Laboratory Animal Sciences (Felasa B), Clinical Trials, a hands-on course in Bioinformatics tools in Clinical Proteomics Data Analysis, and the 5th EACR-OECI Joint Training Course on Molecular Pathology Approach. Bruno has held several research positions, including roles at the Universidade Nova de Lisboa Faculdade de Ciências Médicas (NMS-UNL), Instituto de Medicina Molecular (IMM), and Instituto Nacional de Saúde Doutor Ricardo Jorge IP (INSA). He is also heavily involved in teaching, currently serving as an Assistant Professor at Universidade Lusófona de Humanidades e Tecnologias Escola de Psicologia e Ciências da Vida, Portugal, and as an Invited Assistant Professor at Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal. Bruno works in the area of Medical and Health Sciences with emphasis on Basic Medicine. In his professional activities he has interacted with 154 collaborators and co-authors of scientific papers. Bruno has published 24 peer-reviewed articles and 4 book chapters, supervised 3 MSc dissertations and co-supervised 3.

Graus

• Licenciatura
  Biology
• Doutoramento
  Ciências da Vida
• Pós-Graduação
  Laboratory Animal Sciences (Felasa B)
• Pós-Graduação
  Clinical Trials
• Outros
  COURSE STATISTICAL ANALYSIS USING SPSS IN BIOMEDICINE
• Outros
  5th EACR-OECI Joint Training Course on Molecular Pathology Approach
• Outros
  Hands-on Course - Bioinformatics tools in Clinical Proteomics Data Analysis

Publicações

Journal article

• 2024-12-05, HBM4EU chromates study: the Portuguese integrated and harmonized study on exposure to hexavalent chromium and related early effects, Annals of Work Exposures and Health
• 2023-12, Differential Expression of miRNAs in Amyotrophic Lateral Sclerosis Patients, Molecular Neurobiology
• 2022-10, The Complex Dynamic of Phase I Drug Metabolism in the Early Stages of Doxorubicin Resistance in Breast Cancer Cells, Genes
• 2022-08, The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review, Toxics
• 2022-08, HBM4EU Chromates Study—Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium, Toxics
• 2021-07, Male and female breast cancer: the two faces of the same genetic susceptibility coin, Breast Cancer Research and Treatment
• 2021-03, Biomarkers of effect as determined in human biomonitoring studies on hexavalent chromium and cadmium in the period 2008-2020, Environmental Research
• 2021-02-17, Association Between miR-148a and DNA Methylation Profile in Individuals Exposed to Lead (Pb), Frontiers in Genetics
• 2020-09, Micronuclei Formation upon Radioiodine Therapy for Well-Differentiated Thyroid Cancer: The Influence of DNA Repair Genes Variants, Genes
• 2020-04-23, ABC Efflux Transporters and the Circuitry of miRNAs: Kinetics of Expression in Cancer Drug Resistance, International Journal of Molecular Sciences
• 2020-03-18, The Role of the FMN-Domain of Human Cytochrome P450 Oxidoreductase in Its Promiscuous Interactions With Structurally Diverse Redox Partners, Frontiers in Pharmacology
• 2019-08-01, Thyroid Cancer: The Quest for Genetic Susceptibility Involving DNA Repair Genes, Genes
• 2019-07, Setting up a collaborative European human biological monitoring study on occupational exposure to hexavalent chromium. , Environmental research
• 2019, Regulation of ABCB1 activity by microRNA-200c and microRNA-203a in breast cancer cells: the quest for microRNAs’ involvement in cancer drug resistance, Cancer Drug Resistance
• 2019, MicroRNAs and cancer drug resistance: over two thousand characters in search of a role, Cancer Drug Resistance
• 2018-12-06, Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450, International Journal of Molecular Sciences
• 2018-01, Down syndrome and microRNAs., Biomedical Reports
• 2017-01, Genetic Susceptibility in Acute Pancreatitis: Genotyping of GSTM1, GSTT1, GSTP1, CASP7, CASP8, CASP9, CASP10, LTA, TNFRSF1B, and TP53 Gene Variants.
• 2016-09, Prognostic value of microRNA-203a expression in breast cancer.
• 2016, MicroRNAs and Cancer Drug Resistance.
• 2016, Methods for Studying MicroRNA Expression and Their Targets in Formalin-Fixed, Paraffin-Embedded (FFPE) Breast Cancer Tissues.
• 2013-11, The role of CCNH Val270Ala (rs2230641) and other nucleotide excision repair polymorphisms in individual susceptibility to well-differentiated thyroid cancer.
• 2013-04, Induction of sister chromatid exchange by acrylamide and glycidamide in human lymphocytes: role of polymorphisms in detoxification and DNA-repair genes in the genotoxicity of glycidamide.
• 2010-10, The role of common variants of non-homologous end-joining repair genes XRCC4, LIG4 and Ku80 in thyroid cancer risk.
• 2010-02, Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51.

Thesis / Dissertation

• 2016-12-15, PhD, MICRORNA INVOLVEMENT IN BREAST CANCER SUSCEPTIBILITY AND PROGRESSION

Book chapter

• 2013, DNA Repair and Resistance to Cancer Therapy, New Research Directions in DNA Repair, InTech
• 2011, DNA Repair perspectives in Thyroid and Breast cancer, the role of DNA repair polymorphisms, In-teh
• 2011, DNA Repair Perspectives in Thyroid and Breast Cancer: The Role of DNA Repair Polymorphisms, DNA Repair and Human Health, InTech
• 2010, A Data Mining Approach for the Detection of High-Risk Breast Cancer Groups, Advances in Intelligent and Soft Computing, Springer Berlin Heidelberg

Conference poster

• 2024-12-05, Identifying Alternative Splicing Isoforms in Breast Cancer Cell Lines through Nanopore Sequencing , 28th Annual Meeting Sociedade Portuguesa de Genética Humana
• 2024-12-05, DNA methylation profiling of breast cancer cell lines through Nanopore sequencing, 28th Annual Meeting Sociedade Portuguesa de Genética Humana
• 2022-11-17, Differential Expression of Phase I Drug Metabolism Enzymes in Doxorubicin Resistant Breast Cancer Cells, 26th Annual Meeting Sociedade Portuguesa de Genética Humana
• 2020-12-09, Assessment of microRNAs as Biomarkers of disease progression in amyotrophic lateral Sclerosis, 31st International Symposium on ALS/MND
• 2019-08-28, Occupational Exposure To Hexavalent Chromium - The Portuguese Case Within The Collaborative European Human Biological Monitoring Study, 11th International Symposium on Biological Monitoring in Occupational and Environmental Health (ISBM-11)
• 2019-08-28, A Case Study On Occupational Exposure To Chromium (Vi), Nickel, Pah Mixtures And Lung Cancer, 11th International Symposium on Biological Monitoring in Occupational and Environmental Health
• 2019-07-03, The use of effect biomarkers in hexavalent chromium human biomonitoring studies: a critical review, ISES Europe 2019
• 2018, Probing the role of the hinge segment of cytochrome P450 oxidoreductase in the interaction with cytochrome P450, 9as Jornadas Científicas do IHMT, Instituto de Higiene e Medicina Tropical - Universidade NOVA de Lisboa
• 2018, Probing the Role of the Hinge Segment of Cytochrome P450 oxidoreductase in the Interaction with Cytochrome P450, 2nd NMS Symposium on Chronic Diseases and Translational Science 2018. CEDOC Chronic Diseases
• 2018, Mutants of cytochrome P450 oxidoreductase: probing the role of the hinge segment in the interaction with cytochrome P450s, IV NOVA Health Genetics Workshop, Universidade NOVA de Lisboa Rectorate
• 2017-10, The potential impact of DNA Repair SNPs on DNA damage levels of lymphocytes from 131I-treated thyroid cancer patients, European Society for Pharmacogenomics and Personalized Therapy, 4th Conference
• 2016-09, The potential contribution of DNA repair SNPs to thyroid cancer susceptibility , The potential contribution of DNA repair SNPs to thyroid cancer susceptibility
• 2014-11, miR-200c and miR-203 misexpression in a Portuguese breast cancer population and their association with clinicopathological characteristics, 18th meeting of the Sociedade Portuguesa de Genética Humana
• 2014-11, Immunohistochemistry detection of putative miR-200c and miR-203 Targets in Breast Cancer Patients., 18th meeting of the Sociedade Portuguesa de Genética Humana
• 2013-09-26, Epigenetic alterations of microRNAs 124-1 and 200c during acquired resistance to Imatinib in K562 CML cells, 15th International Conference on Chronic Myeloid Leukemia: Biology and Therapy
• 2013-07-27, Methylation status of selected microRNAs in a Chronic Myeloid Leukaemia cell line (K562) and their relationship with therapy response, 17th ECCO – 38th ESMO – 32nd ESTRO European Cancer Congress
• 2012-09, The role of CCNH Val270Ala and other nucleotide excision repair polymorphisms on individual susceptibility towards thyroid cancer, 6th Santorini Conference Biologie Prospective 2012 - Systems Biology and Personalized Health Science and Translation
• 2011-11-10, Profiling of microRNA expression in breast cell lines of different tumourigenicity, 15th Meeting of the Sociedade Portuguesa de Genética Humana - SPGH
• 2011-04-02, Abstract 4199: Genetic variation in the in vitro genotoxic response to glycidamide and gene expression of DNA repair genes, AACR 102nd Annual Meeting 2011
• 2010-06-06, Polymorphisms in DNA repair genes and non-familiar thyroid cancer risk., The Future of Molecular Epidemiology: New Tools, Biomarkers and Opportunities
• 2009-10-24, Interindividual Variability in the In Vitro Genotoxic Response to Glycidamide: Role of BER and NER Genetic Polymorphisms., Environmental Mutagen Society 40th Annual Meeting
• 2008-05-20, Polymorphisms in genes of the Non-Homologous End-Joining DNA repair pathway and thyroid cancer risk. , Candidate Pathways, Whole Genome Scans: Reconciling Results, Looking into the Future