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Class Toxicology and Pharmacotoxicology

  • Presentation

    Presentation

    The curricular unit (CU) of Toxicology and Pharmacotoxicology aims to provide students with the basic knowledge of Toxicology. This knowledge will be directed to topics related with Medicines and Health Products, from the safety assessment before their approval to the adverse reactions that may arise with the current use. Such knowledge is crucial for the training of pharmacists.  
  • Code

    Code

    ULHT477-8500
  • Syllabus

    Syllabus

    1. Principles of Toxicology  - History and basic concepts - Toxicity tests - Dose / Response relationships - Exposure routes and toxicokinetics 5. Mechanisms of toxicity - Risk assessment - Biomarkers    2. Types of toxic effects and associated drugs/toxicants  - Non-Organ-Directed Toxicity: mutagenesis, carcinogenesis  - Development and Reproductive Toxicology  - Organ-Directed Toxicity: liver, gastro-intestinal, cardiovascular, respiratory, neurological, renal,  dermatotoxicology   3. Safety assessment of novel drugs    4. Relevant types of toxicants  - Metals - toxins from plants, animals and fungi  - pesticides residues - industrial toxicants    5. Environmental impact of medicines and health products   6. Ethanol and abuse drugs   7. Communication in Toxicology
  • Objectives

    Objectives

    - Understand the basic concepts of toxicology, with special emphasis on Pharmacotoxicology - Understand the toxicity tests and the process of risk assessment  - Describe the general mechanisms of toxicity - Describe the main organ-directed and non organ-directed toxic effects and identify representative drugs and toxicants potentially associated - Be able to describe the most relevant food toxicants, such as toxins, pesticides, metals, and industrial contaminants, including their mechanisms of toxicity and the associated health risks. - Be familiar with the legislation related with the safety assessment of novel drugs - development of transversal competences such as the ability to work in groups, the critical spirit, the ability to explain and communicate scientific topics - development of technical skills associated with laboratory work.
  • Teaching methodologies and assessment

    Teaching methodologies and assessment

    Active learning methodologies using Case-based learning  Gamification strategies will be used in classes, through the Kahoot and Wordwall programs. Teaching in the "Fieldwork" format, through study visits and/or seminars with external speakers, as part of the Lusófona Week of Contact with the Pharmaceutical Profession.  
  • References

    References

    Oliveira RD, Carvalho FD, Bastos ML. (2018) Toxicologia Fundamental. Lidel,Portugal. Lee, B-M., Kacew, S.,, Kim, H.S. (2017). Lu's Basic Toxicology (7th edition), CRC Press. Klaassen, C.D. & Watkins, J.B. (2021) Casarett & Doull's: Essentials of Toxicology (4th edition). McGraw-Hill Education Mulder, G. and Dencker, L (2006). Pharmaceutical toxicology: Safety sciences of drugs. London: Pharmaceutical Press.ISBN-100853695938
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