Docente
Marina Badenes

Resume

Marina Badenes completed a Master on Veterinary Medicine at the Faculty of Veterinary Medicine (University of Lisbon) on June 2009, where the Master internship with the title Evaluation of Delta like 4 function in physiological and tumoral angiogenesis was carried out at the Centre of Interdisciplinary Research in Animal Heath and led to two publications on BMC Cancer and PLoS ONE journals, and a thesis award as runner-up in the Health Care Category in the 2013 Future Ideas European Innovation Master Thesis Competition. After this, she enrolled a PhD in Veterinary sciences, specialty of Biomedical and Biological sciences (Reference SFRH / BD / 61125 / 2009) in the same research Centre entitled: In vivo evaluation of the role of Delta-like 4/Notch signaling in the development of intestinal tumors that was completed in February 2016. Since 2011 she is certified as a researcher-coordinator by the Direcção-Geral de Alimentação e Veterinária for the use of experimental animals. The PhD project led to novel and significant findings, published on the thesis and in BMC cancer journal. Within a collaboration, she also found that endothelial Dll4/Notch signaling mediates tumor hypoxia-driven EMT promoting metastization, published on Clinical Experimental Metastasis journal. In another collaboration she characterized a new OprI based system as an enhancer of antigen direct- and cross-presentation and verified the capacity to induce anti-tumoral immune response in mouse, published on Molecular Immunology journal. After the PhD, Marina assumed a Postdoctoral position for 7 years at the Membrane Traffic Lab, at Insitituto Gulbenkian de Ciência, participating on several projects, including the identification of novel trafficking factors for TNF, TNFR I, and P2X7 to identify new strategies to block inflammation, and on the regulatory role of the pseudoprotease iRhom2 on ADAM17 activity, published on Cell reports journal. She validated iRhom tail-associated protein (iTAP), also called FRMD8, as a good candidate to target ADAM17 activity in specific compartments during chronic inflammatory diseases and cancer, published on Life Science Alliance journal. She discovered an endogenous thermogenic inhibitory role of iRhom2/ADAM17 in mouse obesity, acting on adipocytes, and a new adipokine cleaved by ADAM17 called SEMA4B that inhibits differentiation, lipid catabolism and thermogenic capacity in mouse adipocytes. In addition, this work showed evidences that SEMA4B/ADAM17 may contribute for human obesity, which can lead to new therapeutic strategies. These resulted in 2 manuscripts published on Molecular metabolism journal. She was highly involved in the discovery of the inhibitory RHBDL4 role in TLR4-mediated inflammatory disorders by downregulating TMED7 (published on Nature Communications journal). Since September 2022, Marina Badenes is a PI at Animal and Veterinary Research Centre (CECAV) and an Assistant Professor and Coordinator of Citology and Histology at Veterinary Medicine Faculty (Lusófona University) and at Escola Superior de Saúde, Proteção e Bem-Estar of Instituto Politécnico da Lusofonia. She is a collaborator of Instituto de Tecnologia Química e Biológica António Xavier. She has been involved in several funded projects, acquired high technical laboratory skills (in molecular biology, cell culture, immunohistochemistry, confocal microscopy, flow citometry, CRISPR/cas9 genome editing), on mouse disease models, study design and analysis, and scientific writing. She also provided technical/scientific guidance to Master, PhD students, and technicians, and presented her work at numerous national/international conferences, with an awarded oral presentation at UEG Week, and participated in the organization of international scientific events (two EMBO Workshops on Proteostasis, and IGC Sumposium on Crosstalks of of Immunity and Metabolism, being co-chair, and publishing a report at The FEBS Journal, as corresponding author).

Graus

• Mestrado
  Veterinary medicine
• Ensino secundário
  Scienfic field
• Doutoramento
  PhD in Veterinary sciences, specialty of Biomedical and Biological sciences (Reference “SFRH / BD / 61125 / 2009”)

Publicações

Journal article

• 2024-12, Epidermal growth factor receptor pathway in central nervous system regenerative medicine: a narrative review, Regenerative Medicine Reports
• 2024-05, Can the HB-EGF/EGFR pathway restore injured neurons?, The FEBS Journal
• 2024-03-07, RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling, Nature Communications
• 2024, 2023 CBIOS Scientific Seminars - Book of Abstracts, Biomedical and Biopharmaceutical Research
• 2023-07, Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis, Molecular Metabolism
• 2023-04, The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth, Life Science Alliance
• 2020-06-04, Crosstalk between metabolism and immunity: the 3rd Annual Research Symposium of Instituto Gulbenkian de Ciência, The FEBS Journal
• 2020-01, Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis, Molecular Metabolism
• 2019-10-29, iRhom2 and TNF: Partners or enemies?, Science Signaling
• 2017, Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE, Cell Reports
• 2017, Delta-like 4/Notch signaling promotes ApcMin/+ tumor initiation through angiogenic and non-angiogenic related mechanisms, BMC Cancer
• 2015, Immune response profile elicited by the model antigen ovalbumin expressed in fusion with the bacterial OprI lipoprotein, Molecular Immunology
• 2012, Low-Dosage inhibition of DLL4 signaling promotes wound healing by inducing functional Neo-Angiogenesis, PLoS ONE
• 2010, Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis, BMC Cancer

Thesis / Dissertation

• 2016, PhD, In vivo evaluation of the role of Delta-like 4/Notch signaling in the development of intestinal tumors
• 2009, Degree, Avaliação da função de DII4 na neoangiogénese tumoral e fisiológica

Conference abstract

• 2024-01-16, iRhom2/ADAM17 deletion protects from obesity associated to increased adipocyte thermogenesis and differentiation and reduced adipocyte Semaphorin 4B shedding, II Encontro de Investigação da FMV da Universidade Lusófona

Conference poster

• 2020-03-02, Endothelial Dll4 is a multifactorial regulator of tumor metastization, EACR-AACR Basic and Translational Research Conference in partnership with ASPIC: Tumor Microevironment
• 2019-10-07, Endothelial Dll4 loss-of-function reduces metastasis through multiple mechanisms, 2nd EACR-MRS Conference on Seed and Soil: Mechanisms of Metastasis
• 2018-11-16, Metastasis is impaired by endothelial-specific Dll4 loss-of-function through inhibition of epithelial-to-mesenchymal transition, reduction of cancer stem cells and tumour cell intravasation, Exploring the boundaries of animal, veterinary and biomedical sciences. CIISA Congress 2018