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Presentation
Presentation
The aim of this CU is for students to deepen their knowledge of the properties of organic and bioinorganic molecules and their reaction mechanisms. The aim of this CU is to provide a broad multidisciplinary education that gives access to areas of research and development in various sectors of industry and services related to Health.
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Class from course
Class from course
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Degree | Semesters | ECTS
Degree | Semesters | ECTS
Master Degree | Semestral | 6
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Year | Nature | Language
Year | Nature | Language
1 | Mandatory | Português
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Code
Code
ULHT6942-26002
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Prerequisites and corequisites
Prerequisites and corequisites
Not applicable
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Professional Internship
Professional Internship
Não
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Syllabus
Syllabus
1- Organic chemistry and natural products 1.1 Functional groups and their transformation; reaction mechanisms; stereochemistry; bioactive organic compounds and their structure, application in drug synthesis. 1.2 Natural products derived from amino acids, alkaloids, carbohydrates, flavonoids, polyphenols, cannabinoids. Classification and structure. Health applications. 1.3 Structural analysis methods: NMR (1H, 13C). Infrared spectroscopy. Mass spectrometry. 1.4 Research strategies for new bioactive natural compounds 2- Pharmaceutical Inorganic Chemistry 2.1- Essential elements; transition metals and coordination chemistry; crystal field theory 2.2- Biological ligands; Metal complexes in biological systems; Inorganic ions in cells 2.3- Use of metallodrugs, objectives and theory; Design of target molecules for potential drugs; mechanisms of action 2.4- Development of anticancer drugs, antibiotics and drugs for neurodegenerative diseases
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Objectives
Objectives
1-Acquire a global perspective of the field of Organic and Inorganic Chemistry and its applications in the health area 2-Interpret and draw the structures of organic and inorganic molecules 3-Enable students to distinguish natural bioactive molecules extracted from plants, micro-organisms and synthetic molecules and relate their structures to their potential therapeutic application and toxicity 4-Know how to synthesise molecules in the laboratory, purify and identify them 5-Acquire and develop a critical and analytical perspective on chemical issues related to human health. 6- To provide broad multidisciplinary training that gives access to areas of research and development in various sectors of industry and services related to Health. 7- Stimulate individual creativity and multidisciplinary teamwork, critical analysis of the literature, and critical reflection on the use of natural products in the discovery, development, and production of new therapeutic agents.
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Teaching methodologies and assessment
Teaching methodologies and assessment
The curricular unit adopts a face-to-face teaching methodology and active learning and will be taught in the form of lectures with written examples on the board, calling for active student participation, followed by applied exercises and practical classes with laboratory work and seminar presentations with discussion of more specialised topics and interactive debate with the students to provide an overview of the important concepts of reactivity in organic and inorganic chemistry. Support material, exercises and experiment protocols are made available to students. The lectures and practical classes have a dual character: expository and applied. Students are encouraged to take part in solving and discussing problems in class in order to consolidate their knowledge, apply concepts and reaction mechanisms. The laboratory classes will allow students to apply the concepts of synthesis in an experimental environment (Hands-on).
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References
References
1- R. Morrison, R. Boyd, Química Orgânica, Fundação Calouste Gulbenkian, 16 Ed, 2011. 2-Solomons, T.W.G, Fryhle, C.B, Snyder S.A., "Organic Chemistry", 12 th Edition, Wiley, 2016. 2- K. P. Volhardt, N.E. Schore, W.E. Organic Chemistry, Freeman and Company, 6Ed, 2010. 3-P. M. Dewick, Medicinal Natural Products, A Biosynthetic Approach, Wiley, Chichester, 2009.4-5-J.J. Lie, Medicinal Chemistry for practitionners, Wiley & sons Inc., 2020. ISBN: 9781119607281 4- Catherine E. Housecroft and Alan G. Sharpe, Inorganic Chemistry 5th Ed., Pearson, 2018. 5-James C. Dabrowiak Metals in Medicine, 2nd ed., Wiley & sons Inc., 2017. 6-Robert Crichton, Biological Inorganic Chemistry, 3rd Ed., Elsevier, 2019.
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Office Hours
Office Hours
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Mobility
Mobility
No
