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Presentation
Presentation
Natural products are important sustainable sources of bioactive ingredients, with high potential for application in pharmaceutical products, dermocosmetics and food supplements. This curricular unit aims to interrelate the areas of knowledge related to the design and optimization of formulations to deliver bioactives of natural origin depending on the route of administration to be adopted. Taking into account the particular characteristics of bioactives of natural origin, it also aims to systematize the state of the art of delivery systems currently in use and under development, with special emphasis on nanotechnological strategies. Thus, this curricular unit is central to training competitive and innovation-oriented specialists, with a profile for the development and commercialization of products based on bioactives of natural sources.
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Class from course
Class from course
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Degree | Semesters | ECTS
Degree | Semesters | ECTS
Master Degree | Semestral | 6
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Year | Nature | Language
Year | Nature | Language
1 | Mandatory | Português
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Code
Code
ULHT6812-25377
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Prerequisites and corequisites
Prerequisites and corequisites
Not applicable
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Professional Internship
Professional Internship
Não
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Syllabus
Syllabus
Introduction to the design of delivery systems Nanotechnological strategies for delivering natural bioactives Lipid-based nanosystems Polymeric nanosystems Metal-based nanosystems Carbon-based nanosystems Delivery strategies depending on the route of administration: Oral Parenteral Topical and transdermal Ophthalmic, nasal, pulmonary, and auricular Rectal and vaginal
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Objectives
Objectives
This curricular unit (CU) aims to interrelate the areas of knowledge relating to the design and optimization of formulations to deliver bioactive compounds of natural origin depending on the route of administration to be adopted. Considering the particular characteristics of the bioactive compounds of natural origin, it is also intended to systematize the state of the art of delivery systems in use and under development today, with special emphasis on nanotechnology strategies. After attending this course, it is intended that students have acquired the following knowledge, skills, and competences: - understand which properties of the delivery system should be modulated considering the properties of the bioactive compound; - understand which properties of the delivery system should be optimized considering the route of administration to be adopted; - discern the various nanotechnological strategies available for the various routes of administration.
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Teaching methodologies and assessment
Teaching methodologies and assessment
The course is composed of theoretical (T), theoretical-practical (TP), and laboratorial (PL) classes. The T lessons are magisterial following the defined program in accordance with the objectives of the curricular unit. The TP lessons deepen the contents taught, with the respective integration using the active learning strategy based on problems, with exercise resolution and discussion of case studies. The PL classes also include laboratory activities on the preparation and quality control of delivery systems of natural bioactives. The Moodle platform is the official means of communication with students and of providing didactic material.
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References
References
Aulton, M. E., Taylor. K. M. G. (2021) Aulton’s Pharmaceutics: The design and manufacture of medicines (6th Edition). Elsevier. Infarmed. (2008) Farmacopeia Portuguesa (IX Edição). Portugal. Allen, L., & Ansel, H. C. (2021). Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems. (12th Edition). London: Wolters Kluwer Health. Heredia, J. B., Gutiérrez-Grijalva, E. P., Licea-Claverie, A., Gutierrez-Uribe, J. A., Patra, J. K. (2023) Phytochemical Nanodelivery Systems as Potential Biopharmaceuticals. Elsevier.
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Office Hours
Office Hours
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Mobility
Mobility
No
