Class Validation of Analytical Methods

This CU covers the validation of analytical methods within the scope of data analysis methodologies, applying different quantitative analytical techniques. This curricular unit is designed to provide a comprehensive understanding of laboratory quality management and method validation, essential for ensuring the accuracy and reliability of experimental results in various scientific and industrial settings. It covers fundamental principles, methodologies, and standards critical to the competence of testing and calibration laboratories.    

Not applicable

General considerations on the NP EN ISO/IEC 17025 normative. Introduction to method validation Evaluation of experimental errors Robustness, sensitivity, specificity/selectivity Quantification methods Limits of detection and quantification

In this curricular unit, theoretical classes will be supported by different methodologies that support the teaching-learning model, includingsome lectures, but also Project-Based Learning, Flipped Classrooms and Design Thinking, with all learning being consolidated by the bibliography provided. Practical classes will allow students to develop skills by solving theoretical problems using simulation programmes and producing results using spreadsheets built by the students. Practical classes are also important for understanding the knowledge acquired in the theory component.

Barwick, V. (2016). Eurachem/CITAC Guide: Guide to Quality in Analytical Chemistry: An Aid to Accreditation. ISBN 978-0-948926-32-7 Instituto Português da Qualidade (2012). Vocabulário Internacional de Metrologia - Conceitos fundamentais e gerais e termos associados(VIM 2012), edição Luso-Brasileira. Ellison, S.L.R., Williams, A. (2012). Eurachem/CITAC guide: Quantifying Uncertainty in Analytical Measurement, Third Editions. ISBN 978-0-948926-30-3 IPAC (2011). Guia IPAC OGC002. Guia para a Acreditação de Laboratórios Químicos. Relacre. (2018). Guia Relacre 13. Validação de Métodos Internos de Ensaio em Análise Química. ISBN: 972-8574-02-9 Relacre (2018). Guia Relacre 31, Quantificação da Incerteza de Medição em Ensaios Químicos e Físico-Químicos. ISBN: 978-972-8574-46-8 Magnusson B., Örnemark, U. (2014). Eurachem Guide: The Fitness for Purpose of Analytical Methods – A Laboratory Guide to Method Validation and Related Topics. ISBN 978-91-87461-59-0