Class Organic Chemistry I

In this CU solid notions of reactivity and of the necessary skills for the elaboration of the mechanisms associated to the reactions involved in the different classes of compounds taught, will be acquired. The importance of the area of organic synthesis will also be addressed and skills will be acquired to understand the interconversions of functional groups and the relevance of this theme in health. Fundamental capacities for conducting laboratory reactions, will also be acquired and to understand the motives associated with performing certain practical procedures in the execution of reactions, treatment of reaction media, and the isolation and purification of organic compounds. This Curricular Unit (CU) is fundamental within the studies' cycle in which it is inserted, as it allows the acquisition of basic knowledge in the area of organic chemistry and which is essential for the health area.

Not applicable

INTRODUCTION TO ORGANIC CHEMISTRY STEREOCHEMISTRY:Isomerism; Cis/ trans and E/Z classification;Chirality;Enantiomers;Diastereomers; Absolute configuration R/S; Optical activity;Meso compounds;Fischer projections;Resolution of enantiomers. REACTIONS: Substitution/Elimination/Addition/Rearrangement;Covalent bond cleavage; Nucleophiles/Electrophiles; Carbocations/Carbon radicals/Carbanions; Substituent effect, Acidity/Basicity. ALKANES AND CYCLOALKANES: (Structure/Properties/Nomenclature; Conformational analysis; Reactions and mechanisms; Halogenation; Combustion). HALOALKANES: (Structure/Properties/Nomenclature; Synthesis, Reactions and mechanisms; SN1/ SN2 / E1/E2 ; reduction with hydrides); HYDROXYL GROUP: (Structure/Properties/Nomenclature; Synthesis; Organometallic compounds, Reactions and mechanisms with: strong Bases/acids; Carbocations rearrangements);

The teaching methodologies include various instruments based on attending classes (lectures/tutorial) and on other non-attending resources (e.g. Moodle). The approaches used in this course include project-based learning, the use of educational games to teach concepts, and also the use of virtual reality, that allows exploration of molecules and chemical reactions in virtual environments. This UC also includes "Trabalho de campo" teaching through study visits and/or seminars with external guests, as part of the Lusophone Week of Contact with the Pharmaceutical Profession.

David R. Klein, (2017). Organic Chemistry, 3rd edition, Wiley Vollhardt, K. P. C., Schore, N. E., (2014). Organic Chemistry: structure and function, 7th edition, W. H. Freeman. P. Y. Bruice (2017). Organic Chemistry, 8th edition, Pearson. Solomons, T. W. G., Fryhle C. B., Snyder, S.A. (2013). Organic chemistry, 11th ed., Wiley.