Class Biopharmacy

In a global perspective, Biopharmaceutics examines the interrelationship of the physicochemical properties of the drug, the dosage form in which the drug is given, and the route of administration on the observed pharmacological effects. The design of drug products from the respective drugs is based both on pharmaceutical technology and biopharmaceutics to ensure its maneuverability, stability, manageability, i.e., therapeutic success. This CU is of utmost importance for the practice of the pharmaceutical profession in the different intervention areas.

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A. Introduction to Biopharmaceutics B. Pharmacokinetic evaluation of LADMER system Non-compartmental methods C. Release Desintegration, dissolution and solubility D. Absorption Administration routes and drug absorption sites Transmembrane transport Factors that influence the absorption of drugs In vitro and in vivo characterization of the absorption E. Distribution Rate of distribution Apparent volume of distribution Plasma protein binding Tissue distribution F. Biotransformation Enterohepatic recirculation Hepatic microsomal system Phase I/II reactions Factors influencing the metabolism of drugs In vitro and in vivo methods to determine the metabolic clearance Pharmacological interactions G. Elimination Renal and non-renal clearance H. Bioavailability/Bioequivalence I. Biopharmaceutical classification system J. In vitro/in vivo correlations    

The UC consists of theoretical classes and theoretical-practical and practical classes. Theoretical classes are masterful following the program defined according to the objectives of the curricular unit, with stimulation of the active participation of students based on the use of interactive software, such as mentimeter, kahoot and kialo. Theoretical-practical classes deepen the content taught in the theoretical component, focusing on problem solving. Multimedia learning and the use of search engines (Pubmed, Scopus...) are used for students to develop their group work, focusing on the influence of the various specific populations and clinical situations that have an impact on pharmacokinetics.

SHARGEL, L. & YU, A.B.C. (2012) Applied Biopharmaceutics and Pharmacokinetic (7th Ed). New York: McGraw-Hill. Jambhekar, S.S. & Breen, P.J. (2012) Basic Pharmacokinetics (2nd Ed). Pharmaceutical Press.